赤霉素及其功能类似物与赤霉素受体的研究进展

Progress on gibberellins,gibberellins functional analogues and gibberellins receptor

赤霉素是一类以贝壳杉烯为骨架的植物激素,现已鉴定出136种赤霉素结构,但仅有少部分具有调节植物生长和发育的生理功能。近年来,赤霉素受体的研究取得了重大突破,尤其是最近成功鉴定了拟南芥Arabidopsis thaliana中GA3/GA4-GID1A-DELLA复合物的晶体结构,这为基于受体蛋白结构进行新型赤霉素功能类似物的生物合理设计奠定了重要基础。主要针对赤霉素及其功能类似物的化学结构与合成、赤霉素受体蛋白的结构特征及其与赤霉素类化合物分子间的相互识别规律进行归纳和总结,以期能够为以生物靶标蛋白为导向,开发新型骨架的赤霉素功能类似物提供参考。

Gibberellins （GAs） are a large family of tetracyclic, diterpenoid plant hormones that induce a wide range of high plant growth responses. Since the first discovery of GA3 in the Gibberella fujikuroi fungus, 136 GAs have been identified from different plant, fungi and bacteria. However, only a few GAs were active growth regulators in the seed plant. Recently, the complex crystal structures of GA receptor GID1A with GA3 and GA4 were successfully identified, which would provide a good chance for the rational design of novel GA functional analogues based on the GA receptor GID1 structure. The research progress on structure and synthesis of GA and its functional analogues, the structural characters of the GA receptor GID1, and the GA recognition mode to the GA receptor GID1 protein was reviewed. It was hopeful that these studies would be beneficial in discovering some novel potential GA-like functional molecules based on GID1.