尿频康对大、小鼠排尿的抑制作用及药动学实验

Studies of Niaopinkang for Inhibiting Urination and Pharmacokinetics in Mice and Rats

:尿频康 5～ 2 0 g/ kg灌胃给药 ,对正常、水负荷和注射速尿后大、小鼠的排尿均有抑制作用。表现为1h内的排尿次数、排尿量减少。口服 0 .5h起效 ,1h达高峰 ,持续时间 7h。尿频康体内过程呈二室模型 ,2 h前为分布相 ,2 h后为消除相。效量半衰期 [t1/ 2 ( ED) ],α相为 0 .737h,β相为 5.4 2 8h。表观半衰期 α相 0 .82 7h,β相5.84

Niaopinkang at the doses of 5～20 g/kg decreased the times and volume of urination in the mice and rats receiving ip water or furosemide. The duration of action after oral administration is from 0.5 to 7h. The behavior of Niaopinkang was showed by two compartment model using residual rate and effect dose relationship. Results indicated that the apparent t 1/2 and effect dose t 1/2 were 5 428 h and 5 847 h, respectively.