乳腺癌患者手术后局部复发的临床分析

Clinical analysis of local recurrence of breast cancer after operation

目的探讨乳腺癌患者手术后局部复发的影响因素。方法回顾性分析2000年至2008年诊治的671例患者的临床病理资料,行Cox回归模型分析预后影响因素。结果手术后局部复发率为10.7%,Cox回归模型多因素分析显示,淋巴结状态、肿瘤分期、激素受体状态、术后规范化辅助治疗是影响手术后局部复发的重要因素,其中手术后规范化辅助治疗是其保护性因素。结论淋巴结状态、肿瘤分期、激素受体状态、术后规范化辅助治疗对患者的预后评估有重要意义,术后行规范化辅助治疗可降低局部复发。

Objective To explore the influence factors of local recurrence after resection of breast cancer. Methods A retrospective clinical and pathological data of patients hospitalized from 2000 to 2008 were reviewed. Prognostic factors were analyzed by Cox regression model. Results The postoperative local recurrence rate reached 10. 7%. Multivariate Cox regression model analysis showed that tumor stage,lymph node status, hormone receptor status, postoperative standardized treatment are important factors influencing postoperative local recurrence, and the standardized treatment was the protective factor. Conclusions Lymph node status, hormone receptor status ,tumor stage, postoperative adjuvant treatment are important for patient prognosis, and regular postoperative auxiliary treatments help reduce rate of postoperative local recurrence.