2005—2012年浙江省衢州市肾综合征出血热监测分析

Surveillance for hemorrhagic fever with renal syndrome in Quzhou,Zhejiang,2005-2012

目的 掌握浙江省衢州市肾综合征出血热（HFRS）流行特征和宿主动物分布特点。方法 收集衢州市2005-2012年HFRS人间和鼠间疫情资料进行分析。结果 衢州市8年间共报告HFRS 424例，死亡2例，年平均发病率为2.28/10万，病死率为0.47%，发病率呈逐年下降趋势。患者以30~69岁为主，占85.38%，农民占79.95%，男女性别比为2.50：1。季节高峰呈夏季和冬季双峰型，以开化县山区发病率最高。室内以褐家鼠为优势种，占57.39%；室外以黑线姬鼠为优势种，占76.04%。鼠类HFRS带病毒率为2.02%，鼠血清HFRS抗体阳性率为4.35%。结论 衢州市广泛分布姬鼠型为主的混合型HFRS疫区，仍需加强本病监测、灭鼠和疫苗接种工作。

Objective To understand the epidemiological characteristics of hemorrhagic fever with renal syndrome （HFRS） in Quzhou, Zhejiang province. Methods The analysis was conducted on surveillance data of HFRS in Quzhou from 2005 to 2012. Results A total of 424 HFRS cases, including 2 deaths, were reported during this period. The average annual incidence was 2. 28/lakh and the case fatality was 0. 47%. The incidence declined by year. Most cases were aged 30 -69 years （85. 38% ）. The cases in farmers accounted for 79. 95%. The male to female ratio of the cases was 2. 50： 1. Incidence peaks were in summer and in winter. The nighest incidence was found in Kaihua mountain area. Ranus norvegicus was the predominant indoor host animal （57. 39% ）, and Apodemus agrarians was the predominant outdoor host animal （76.04%）. The hantavirus carrying rate was 2. 02% in rodents, and the serum antibody positive rate of hantavirus in rats was 4. 35%. Conclusion HFRS epidemic area with Apodemus as predominant host animal exists in Quzhou. It is still necessary to strengthen HFES surveillance, deratization and vaccine immunization.