术后禁食患者肠通透性的变化

Changes of intestinal permeabiloty of postoperative fasting patients

目的 测定术后病人肠通透性 ,评价其肠屏障功能。方法 2 0例中等大小手术的病人 ,术后禁食 3～ 5 d,肠功能恢复时 ,口服乳果糖 (L )和甘露醇 (M)溶液 ,收集 6 h尿液 ,用高压液相色谱议测定尿中 L和 M,计算其排泄比率 (L / M)。选 2 0例健康志愿者为对照 ,两组的年龄、性别无统计学差异。结果 术后禁食病人的 L / M为 0 .1989± 0 .1186 ,健康志愿者为 0 .4398± 0 .2 16 5 ,两者有显著性差异 (P <0 .0 5 )。结论 与健康志愿者比较 。

Objective To measure intestinal permeability of postoperative fasting patients and evaluate their intestinal barrier function.Methods Twenty patients after moderate or minor operation ,10 male and 10 female,were included in the study .After 3 to 5 days of fasting,when their bowel functon returned to normal,10 ml solution of lactulose(2g) with mannitol (1g) were given orally,urine of 6 hours was collected.As a control group,20 healthy volunteers were also included.There were no statistical differences in sex and age between two groups.Results The L/M of the patients and healthy volunteers were 0.1989±0.1186 and 0.4398± 0.2165 respectively,the difference was significant.Conclusions The intestinal permenbility of postperative fasting patients was elevated when compared with that of volunteers.