高原肺水肿治疗前后血清心肌肌钙蛋白T的变化

The change of plasma cardiac troponin T level in patients with high altitude pulmonary edema before and after treatment

目的 探讨诊断和判别高原肺水肿 ( HAPE)状态的新指标。 方法 在海拔 3 70 0 m处对 8例 HAPE患者在治疗前及临床治愈后分别测定血清肌酸激酶同功酶 ( CK- MB)和 c Tn T两项指标。 结果 HAPE患者血清 CK- MB和 c Tn T临床治愈后较治疗前均降低 ,二者间的差别有非常显著性意义 ( P<0 .0 1)。 结论 HAPE时存在心肌损伤 ,血清 c Tn T是一项具有高灵敏度、高特异性的血清心肌损伤标志物 ,对 HAPE的诊断、病情分析有一定的价值。

Objective To explore a new index for diagnosis of high altitude pulmonary edema (HAPE) and judgement of the state of it. Method Plasma levels of creatine kinase MB (CK-MB) and cardiac troponin T (cTnT) of 8 patients suffering from HAPE were measured in a medical station at 3700 m altitude before recieving treatment and after recovery. Results The plasma levels of CK-MB and especially cTnT in patients with HAPE after recovery were significantly lower than those before treatment (P<0.01). Conclusion The results indicate that there is myocardial injury in patients with HAPE, and cTnT is an useful index for diagnosis of HAPE and judgement of state of it.