摘要
目的:探讨缬沙坦对大鼠急性心肌梗死后心室重构和血浆脑钠肽(BNP)、内皮素-1(ET-1)的影响。方法:首先制作大鼠急性心肌梗死模型,然后将手术完成后存活下来的大鼠随机分为三个组,即心肌梗死+缬沙坦组、心肌梗死组与对照组,使用缬沙坦对缬沙坦组大鼠进行治疗,检测1个月后大鼠体内的血浆脑钠肽(BNP)浓度、内皮素-1(LVESD)浓度和心室重构(LVEDD)情况。结果:与心肌梗死组相比,缬沙坦能显著缩小心室重构指标(LAD、LVESD、LVEDD)并降低了血浆BNP、ET-1水平(P<0.01),两组间差异有统计学意义。结论:使用缬沙坦治疗大鼠30d,心肌梗死的大鼠的心室重构得到抑制,血浆脑钠素、内皮素-1水平也明显降低,大鼠心功能得到显著改善。
Objective ： To observe the effects of the valsartan on serum brain natriuretic peptide（BNP）, serum endothelin -1 （ET-1） and heart remodeling after acute myocardial infarction of rats. Methods ：90 male wister rats were randomly divided into three groups ： ① sham group （n = 30） ; ②AMI group （n = 30） ; ③ AMI ＋ valsartan group（n=30）. Rats in the AMI＋valsartan group were given the valsartan. Rat＇s serum concentrations of BNP and ET-1 were tested at 30th day after operation while heart remodeling（LAD, LVESD, LVEDD） were measured. Re- suits ：Compared with AMI Group, the blood serum levels of BNP and ET-1 in AMI＋valsartan Group rats was smal- ler（P^0.05）, and similarly LAD,LVESD,LVEDD in AMI＋ valsartan Group rats were smaller too. Conclusions： This showed that the valsartan can lessen the increase of BNP and ET-1 blood serum levels and delay the remodeling progress of AMI at 30th day after operation.
出处
《陕西医学杂志》
CAS
2013年第12期1576-1578,共3页
Shaanxi Medical Journal
基金
河北省邯郸市科学技术研究与发展计划(1223108086-8)
