左卡尼汀对老年维持性血液透析患者炎症、营养不良和贫血的影响研究

Impact of L-carnitine on microinflammation,malnutrition and anemia in elderly patients with maintenance hemodialysis

目的:探讨左卡尼汀(L-CN)对老年维持性血液透析(MHD)患者炎症、营养不良和贫血的影响。方法:46例老年MHD患者随机分为两组,对照组予常规治疗,观察组加用左卡尼汀,比较两组患者治疗前后血IL-6、hs-CRP、Alb、PAB、Hb、HCT等指标的差异。结果:治疗12周后,观察组患者血清IL-6、hs-CRP较治疗前显著下降,Alb、PAB、Hb、HCT显著上升,对照组Hb、HCT较治疗前显著上升,差异有统计学意义(P<0.05),但明显低于观察组,差异有统计学意义(P<0.05);对照组治疗后血IL-6、hs-CR及Alb、PAB与治疗前比较无统计学差异(P>0.05)。结论:老年MHD患者普遍存在L-CN缺乏,L-CN治疗可以改善患者微炎症及营养不良状态,纠正肾性贫血。

Objective：To investigate the impact of L-carnitine on microinflammation, malnutrition and a- nemia in elderly patients with maintenance hemodialysis（MHD） . Methods：46 elderly MHD patients were randomly divided into two groups, the control group received conventional treatment, the observation group were treated with L-carnitine, the serum IL-6, hs-CRP, AIb, PAB, Hb, HCT were compared. Results：After 12 weeks, the levels of serum IL-6, hs-CRP were decreased significantly than before treatment, the Atb, PAB, Hb, HCT were increased , and in the control group the Hb, HCT were increased , the difference was of statistically significant （P〈0.05）, but the Hb, HCT was significantly lower than that in the observation group（P 〈0.05） ; there was no significant differ- ence in control group after treatment in serum IL-6, hs-CR and Alb, PAB （P〉 0.05）. Conclusion：MHD patients with low levels of L-CN, and L-CN therapy can improve micro-inflammation and malnutrition status and renal anemia.