丹参多酚酸盐对慢性阻塞性肺疾病急性加重期患者血清IL-1β、IL-18水平的影响

Effects of Salvianolate Injection on the Levels of Serum L-1β and IL-18 in Acute Exacerbated Chronic Obstructive Pulmonary Disease Patients

[目的]观察丹参多酚酸盐注射液对慢性阻塞性肺疾病急性加重期(acute exacerbations of chronic obstructive pulmonary disease,AECOPD)患者血清白细胞介素-1β(IL-1β)、白细胞介素-18(IL-18)水平的影响。[方法]选取2013年1月至2013年6月在浙江中医药大学附属杭州第三医院呼吸科病房确诊为AECOPD患者,随机分成对照组30例,治疗组28例。对照组予以常规治疗,治疗组在对照组基础上加用注射用丹参多酚酸盐200mg溶于5%葡萄糖注射液250mL中静滴,两组均在治疗前后检测动脉血气分析、血清IL-1β、IL-18水平,并与由30名健康体检者组成的正常对照组的血清IL-1β、IL-18结果进行对照。[结果]治疗前AECOPD患者血清IL-1β、IL-18水平较正常对照组明显升高(P<0.01),治疗后对照组和治疗组患者上述指标较前均有明显改善(P<0.05),并且治疗组优于对照组(P<0.05)。[结论]丹参多酚酸盐注射液可降低AECOPD患者血清IL-1β、IL-18水平,其作用机制可能与抑制慢性阻塞性肺疾病患者炎症反应的表达有关。

[Objective] To investigate the effect of salvianolate injection on the levels of Serum interleukin - 113 （IL- 113）and interleukin - 18 （IL- 18） in acute exacerbated chronic obstructive pulmonary disease（AECOPD） patients. [Methods] Fifty-eight patients with acute exacerbated COPD from Respiratory Dep. of thrid Hospital Affdiated to Zhejiang Chinese Medical University, were randomly assigned to the treatment group（28 cases） and the control group（30 cases）. Routine therapies for COPD were given to patients in the control group, while 20mg salvianolate injection was given to those in the treatment group by intravenous dripping, once daily for total 10 days. The levels of IL-18, IL-113 and blood gas analysis were evaluated before and 10 days after therapy. The levels of the cytokins were compared with 30 normal controls. [Result] There were no significant differences in the value of IL- 1β,IL-18,arterial partial pressure of carbon dioxide（PaCO2）,arterial partial pressure of oxygen（PaO2） before treatment between two groups. Compared with the blank control group, the levels of serum IL-1β,IL-18 in patient with AECOPD were increased significandy（P〈0.01）. When compared with before treatment and with the control group, the levels of IL-1β,IL-18,PaCO2 decreased more significantly in the treatment group after treatment.The PaO2 in treatment group was higher than in control group. There were significant differences between two groups. [Conclusions] Salvianolate injection can reduce the secretion IL-1β, IL-18 in patient with AECOPD, which maybe through certain anti-inflammatory effects to improve chnical efficacy of COPD patients.