眼睑皮肤松弛综合征临床研究进展

Diagnosis and treatment of the blepharochalasis syndrome

眼睑皮肤松弛综合征是一种较少见的眼睑疾病，表现为青少年时期特发性局限性眼睑皮肤反复间断性无痛性血管神经性水肿，反复水肿破坏眼睑组织结构导致眼睑皮肤松弛变薄，毛细血管增多迂曲扩张以及后期上睑下垂、眶脂肪脱垂、泪腺脱垂等多种并发症。眼睑皮肤松弛综合征的发病机制尚不明确，可能存在遗传等因素的参与；组织病理学研究发现IgA沉积和基质金属蛋白酶活性表达增强，提示免疫反应参与弹性纤维的降解，后者进一步引起局部淋巴系统结构功能的改变；这些因素共同参与了本病的发生发展。眼睑皮肤松弛综合征的治疗分为急性水肿期和稳定期的治疗。

Blepharoehalasis syndrome is a rare eyelid disease that often presents in childhood or ad- olescence. It is characterized by idiopathic localized intermittent painless edema of upper and（or） lower eye- lids, which would destroy the tissue structure of eyelid and lead to atrophic, wrinkled periorbital skin and the tortuous and dilated capillaries. Other clinical manifestations include proptosis, prolapse of orbital fat, and lacrimal tissue, etc. The etiology of the blepharochalasis syndrome has not yet to be fully elucidated. It still cannot exclude the participation of genetic factors. IgA and matrix metalloproteinases had been found in the periorbital tissues, which confirm that participation of the immuoreaction which might lead to elastolysis. Elastolysis may ruin the structure and the function of the lymphatic system. All these factors may play a sub- stantial role in the pathogenesis of the disease. The treatment of blepharochalasis divided into the treatment of acute edema and stable oeriod.