预测及筛查原发性闭角型青光眼高危人群的研究进展

Research advances of predicting and screening for the primary angle closure glaucoma

危险窄房角者若能在急性房角关闭及周边虹膜前粘连形成之前筛查出高度可疑前房角关闭者，可早期阻断发病环节，对防止演变成原发性闭角型青光眼（primaryangleclosureglaucoma，PACG）具有重要意义。PACG的预测及筛查方法中，前房角镜检查、超声生物显微镜、眼前段相干光断层扫描、Scheimpflug照相技术有各自的优缺点。预测及筛查PACG涉及众多的眼球生物学参数测量，最新的研究进展涉及静态参数与动态参数。前者包括前房深度、宽度、体积、面积，房角开放程度参数，虹膜厚度、体积、曲率，晶状体厚度、相对位置、拱高等；后者包括虹膜容积变化测量及葡萄膜渗漏检查等。

If the high-risk groups of primary angle closure glaucoma can be screened betore acute angle closure attacks or peripheral anterior synechia formation among anatomically narrow angle eyes, and proper prophylactic treatment can be performed in time, subsequent glaucomatous optic neuropathy can be prevented. Each of those methods, such as gonioscopy, ultrasound biomicroseopy, anterior segment optical coherence tomography and Scheimpflug photograph, has advantages and drawbacks. Latest research shows predicting and screening for PACG involved with fairly wide range of biometric ts, including the parameters on anterior chamber, angle opening degree, iris, lens, volume change of iris, and uveal effusion as well. This article briefly reviews research advances in predicting and screening methods for high risk cases of the primary angle closure glaucoma.