摘要
目的:研究子宫内膜异位症腹腔镜手术后联合米非司酮药物治疗的效果及安全性。方法:将232例子宫内膜异位症腹腔镜手术后的患者随机分为3组:米非司酮组(RU486)84例,孕三烯酮组78例,未用药组70例。比较3组术后疗效、术后复发、妊娠及用药不良反应等情况。结果:米非司酮组、孕三烯酮组复发率分别为5.95%、6.41%,低于未用药组45.71%(P<0.05,P<0.05)。米非司酮组不良反应发生率15.48%,低于孕三烯酮组46.15%(P<0.05)。米非司酮组和孕三烯酮组的术后复发率没有显著性差异,对照组术后有效率明显较其它两组低,复发率亦较其他两组高,差异均具有统计学意义(P<0.01),3组术后妊娠率差异无统计学意义。结论:腹腔镜术后联合米非司酮或孕三烯酮治疗子宫内膜异位症较单纯手术复发率低、治疗效果可靠,而且米非司酮的价格低廉,不良反应显著小于孕三烯酮。
Objective：To study endometrio- sis after laparoscopie surgery and gestrinone mifepristone effects of the drug and safety. Methods：232 cases of uterine endometriosis after laparoscopic surgery were randomly di- vided into 3 groups：mifepristone group of 84 patients,78 patients in gestrinone group,70 patients with untreated group.Comparative efficacy of group 3 patients,recurrence,preg- nancy and medication side effects and so on. Results：The mifepristone group,the recurrence rate within the gestrinone group was 5.95% ,6.41% ,lower than the no treatment group 45.71% （P〈 0.05,P〈 0.05）.The inci- dence of side effects of mifepristone group 15.48% ,lower than the gestrinone group 46.15% （P〈 0.05）.Mifepristone group and the gestrinone group,the recurrence rate was not significant（P〉0.05）,the control group were significantly lower efficiency the other two groups（P〈 0.01）,relapse rates were sig- nificantly higher than the other two group（P〈0.01）,3 no significant difference in pregnancy rate after operation.Conclusion： Laparoscopic surgery combined with mife- pristone or gestrinone treatment of endome- triosis recurrence rate compared with surgery alone,the treatment effect is reliable, and inexpensive mifepristone adverse reac- tion was significantly less than the gestrinone worthy of clinical application and pro- motion.
