甲状腺乳头状癌雌激素受体的表达及对雌激素反应性的研究

EXPRESSION OF ESTROGEN RECEPTORS AND THE RESPONSIVENESS TO ESTROGEN IN PAPILLARY CARCINOMA

目的 探讨甲状腺乳头状癌中雌激素受体 (ER)的表达及雌激素对其生长的影响。方法 应用免疫组化、原代培养和溴脱氧尿核苷标记 (BrdULI)技术对 70例女性甲状腺乳头状癌ER表达和雌激素对培养肿瘤细胞增生活性的影响进行研究。结果 甲状腺乳头状癌中ER表达率为 41% (2 9/70 ) ,ER阳性的甲状腺乳头状癌BrdULI随着雌二醇 (E2 )的增加而增高。结论 甲状腺乳头状癌是雌激素依赖性肿瘤 ,雌激素可以影响ER阳性的乳头状癌的生长活性。

Objective To investigate the expression of ER in papillary thyroid carcinoma and the responsiveness to estrogen. Methods We have immunohistochemically studied estrogen receptors(ER) in 70 cases of papillary thyroid carcinoma in women and investigated the responsiveness to estrogen of thyroid neoplasms using primary culture of surgically resected thyroid tissues. The proliferative activity of cultured cells was measured by the bromodeoxyuridine(BrdU) labeling index(LI). Results 41%of papillary thyroid carcinoma (29/70) showed positive staining of ER. The BrdU LI of ER-positive papillary thyroid carcinoma increased with the addition of estradiol. Conclusion these findings indicate that papillary thyroid carcinoma is the tumor depending on estrogen and estrogen may affect the proliferation of ER-positive papillary thyriod carcinomas.