期刊文献+

化疗在局部晚期鼻咽癌中的适度应用 被引量:2

Appropriate Application of Chemotherapy in Locally Advanced Nasopharyngeal Carcinoma
下载PDF
导出
摘要 鼻咽癌是我国高发恶性肿瘤之一,发病率为头颈部恶性肿瘤之首。鼻咽癌对放疗、化疗均敏感。单纯的放射治疗虽然能够使早期患者获得很好的局部控制率,但是对于局部晚期患者而言,其5年生存率难以令人满意,治疗失败主要是因为区域复发和远处转移。化学治疗对放疗起到了补充作用,临床应用目前主要有同期化疗、辅助化疗、诱导化疗三种。本文对过去20年间化疗在局部晚期鼻咽癌治疗中的应用归纳总结。 Nasopharynx carcinoma of nasopharynx is common in China. Among head and neck malignant tumors, it has the highest incidence rate. Nasopharyngeal cancer is sensitive to both radiotherapy and chemotherapy. For early-stage naso pharyngeal carcinoma patients, radiotherapy alone may attain good local control, however, for locally- advanced patients, the 5-years overall survival rate of radiotherapy is hardly satisfied. Regional recurrence and distant metastasis are two major reasons for the treatment failure. As a complementary method, Chemotherapy plays an important role in the treatment of nasopharyngeal cancer. In clinical applications, three types of chemotherapy are mostly used., concurrent chemotherapy, adjuvant chemotherapy and induction chemotherapy. This paper summarized the treatment of chemotherapy for locally-advanced nasopharyngeal carcinoma treatment in the past 20 years.
作者 张帆 易峰涛
出处 《医学与哲学(B)》 2013年第11期56-58,共3页 Medicine & Philosophy(B)
关键词 鼻咽癌 化疗 适度治疗 nasopharyngeal chemotherapy appropriate treatment
  • 相关文献

参考文献14

  • 1Al-Sarraf M,Pajak T F,Cooper J S,et al.Chemo-radiotherapy in patients with locally advanced nasopharyngeal carcinoma:a radiation therapy oncology group study[J].J Clin Oncol,1990,8(8):1342-1351.
  • 2Al-Sarraf M,LeBlanc M,Giri P G,et al.Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer:phase Ⅲ randomized Intergroup study 0099[J].J Clin Oncol,1998,16(4):1310-1317.
  • 3Chan A T,Teo P M,Ngan R K,et al.Concurrent chemotherapy-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma:progression-free survival analysis of a phase Ⅲ randomized trial[J].J Clin Oncol,2002,20(8):2038-2044.
  • 4Chan A T,Leung S F,Ngan R K,et al.Overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma[J].J Natl Cancer Inst,2005,97(7):536-539.
  • 5Lin J C,Jan J S,Hsu C Y,et al.Phase Ⅲ study of concurrent chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma:positive eff ect on overall and progression-free survival[J].J Clin Oncol,2003,21(4):631-637.
  • 6Zhang L,Zhao C,Peng P J,et al.Phase Ⅲ study comparing standard radiotherapy with or without weekly oxaliplatin in treatment of locoregionally advanced nasopharyngeal carcinoma:preliminary results[J].J Clin Oncol,2005,23(33):8461-8468.
  • 7Rossi A,Molinari R,Boracchi P,et al.Adjuvant chemotherapy with vincristine,cyclophosphamide and doxorubicin after radiotherapy in local-regional nasopharyngeal cancer:results of a 4 year multi-center randomized study[J].J Clin Oncol,1988,6(9):1401-1410.
  • 8Wee J,Tan E H,Tai B C,et al.Randomized trial of radiotherapyversus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage Ⅲ and IV nasopharyngeal cancer of the endemic variety[J].J Clin Oncol,2005,23(27):6730-6738.
  • 9Chen Y,Liu M Z,Liang S B,et al.Preliminary results of a prospective randomized trial comparing concurrent chemoradiotherapy plus adjuvant chemotherapy with radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma in endemic regions of China[J].Int J Radiat Oncol Biol Phys,2008,71(5):1356-1364.
  • 10Lee A W,Tung S Y,Chua D T,et al.Randomized trial of radiotherapy plus concurrent-adjuvant chemotherapy vs radiotherapy alone for regionally advanced nasopharyngeal carcinoma[J].J Natl Cancer Inst,2010,102(15):1188-1198.

同被引文献14

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部