强直性脊柱炎生物治疗的现状及新进展

Present Status and New Progress of Biotherapy Treating Ankylosing Spondylitis

强直性脊柱炎是一种以脊柱病变为主的慢性病,累及骶髂关节,引起脊柱强直和纤维化,造成不同程度的眼、肺、肌肉、骨骼病变,属自身免疫性疾病。强直性脊柱炎的致病机制仍未完全明了,但在治疗方面,生物治疗策略取得了可喜的新经验,生物药物展现出良好的应用前景。

Ankylosing spondylitis（AS） is a kind of chronic disease by involvement of the main spine, involving the sacroiliac joints, causing stillness and fibrosis spine, resuhing in varying degrees of eye, lung, muscle, bone diseases, and iffs a autoimmune diseases. With the AS-depth study of risk factors, although its pathogenic mecha- nisms are not yet fully understood, but in terms of treatment, biotherapy treatment strategies has made encouraging new experience, and the biological products are showing good prospec, ts.