血清视黄酸结合蛋白与冠状动脉造影后造影剂肾病发生相关性的研究

Study of correlation of the serum retinol- binding protein in serum and contrast-induced nephropathy occurred after coronary angiography

目的：探讨血清视黄酸结合蛋白（sRBP）与冠状动脉造影后造影剂肾病（CIN）发生的相关性。方法采用回顾性研究的方法，选择接受冠状动脉造影术和（或）经皮冠状动脉介入治疗术的冠心病患者为研究对象，收集患者造影前24h内、造影后8h、24h和48h血视黄酸结合蛋白、血清肌酐等相关临床资料。结果CIN组的sRBP在造影前24h内即出现升高，在冠状动脉造影后8h明显升高，24-48h仍持续升高；与非CIN组相应时间点相比，CIN组患者的sRBP显著增高（P＜0.05）。造影前sRBP升高与CIN发生有相关性。结论 sRBP可能是预测和判断CIN发生的一个较好的血液学指标。

Objective To investigate correlation of the serum retinol- binding protein （sRBP） and contrast-induced nephropathy （CIN） occurred after coronary angiography. Methods A retrospective study to patients with coronary artery disease, undergoing coronary angiography and （or） percutaneous coronary intervention,sRBP, serum creatinine and other relevant clinical data were collected within 24h before angiography, angiography after 8h, 24h and 48h. Results The sRBPof CIN group appears within 24h before coronary angiography,increased 8 h after coronary angiography was significantly higher,24h to 48h remained elevated;and compared with non-CIN group to the corresponding point in time, CIN sRBP group of patients was significantly higher （P〈0.05）. Before angiography sRBP increase correlated with the incidence of CIN. Conclusion sRBP may be better haematological indices to predict and judge CIN occurred.