布地奈德雾化吸入治疗96例慢性阻塞性肺疾病急性加重期疗效观察

Efficacy of budesonide inhalation treatment of 96 patients with COPD acute exacerbation

目的：观察布地奈德雾化吸入对慢性阻塞性肺疾病急性加重期的疗效。方法选择2009年1月～2012年12月在我院住院的慢性阻塞性肺疾病急性加重期的患者96例，随机分为观察组和对照组，两组均为48例。对照组给予吸氧、抗感染、支气管扩张剂、化痰、甲泼尼龙静脉点滴40mg次，每日1次。观察组在对照组治疗基础上同时给予布地奈德雾化吸入，2mg/次，2次/d。治疗1周后观察两组治疗前后FEV1、FEV1/FVC、PaO2、PaCO2等指标改善情况。结果两组患者治疗后肺功能指标PaO2、PaCO2、FEV1、FEV1/FVC）均较治疗前有显著改善（P＜0.01），但治疗后观察组与对照组相比上述指标差异有统计学意义（P＜0.05）。观察组：显效19例，有效25例，总有效率为91.7%；对照组：显效14例，有效23例，总有效率为77.1%。两组比较差异有统计学意义（P＜0.05）。结论局部及全身应用糖皮质激素类药联合治疗慢性阻塞性肺疾病急性加重期临床效果显著，值得借鉴。

Objective To observe the therapeutic effect of inhaled budesonide aerosol on patients with acute phrase of chronic obstructive pulmonary disease. Methods 96 patients with chronic obstructive pulmonary disease of acute exacerbation from January 2009 to December 2012 in our hospital were chosen, who were randomly divided into observation group and control group, every group were 48 cases. Patients in control group were given oxygen, antibiotics, bronchodilators, phlegm, intravenous methylprednisolone 40 mg once a day. The patients in observation group were given additional budesonide inhalation, 2mg/time, 2 times/d. Results The indicators were observed before and after treatment, such as FEV1, FEV1/FVC, PaO2, PaCO2,and so on. After one week treatments, pulmonary function PaO2, PaCO2, FEV1, FEV1/FVC） were significantly improved than before treatment （P〈0.01）, and compared with the control group the observed group was above indexes significantly different （P〈0.05）. 19 cases of observation group were markedly effective in 25 cases, total effective rate was 91.7%; 14 cases of control group markedly effective in 23 cases, total effective rate was 77.1%. There was significant difference between the two groups （P 〈 0. 05）, with statistical significance. Conclusion This study illustrates that local and systemic corticosteroid drugs treatments of chronic obstructive pulmonary disease with acute exacerbation have significant clinical effect.