血清诱捕受体3的水平与膀胱移行细胞癌的关系

Association of serum decoy receptor 3 protein level with the clinicopathologic features of bladder transitional cell carcinoma

目的探讨诱捕受体3(DcR3)蛋白在膀胱移行细胞癌患者血清中的表达水平及其与膀胱移行细胞癌发生发展的关系。方法采用用酶联免疫吸附试验(ELISA)检测膀胱移行细胞癌患者血清DcR3的水平,分析其与患者年龄、性别、膀胱移行细胞癌病理分级及临床分期的关系。结果膀胱移行细胞癌患者血清中DcR3[(183.43±78.45)pg/m1]的水平明显高于正常人[(116.65±97.43)pg/m1],差异有统计学意义(P<0.05)。膀胱移行细胞癌患者血清DcR3水平与肿瘤的TNM分期、病理分级密切相关(P<0.05);与患者的年龄、性别无关(P>0.05)。结论 DcR3表达水平可能与膀胱肿瘤的恶性程度密切相关。

Objective To investigate the association of serum levels of decoy receptor 3（DcR3） protein and the clinicopathologic features of bladder transitional cell carcinoma. Methods Enzyme-linked immunosorbent assay was used to examine the serum levels of DcR3 in patients with bladder transitional cell carcinoma for analysis of its association with the patients＇ age, gender, clinical stages and pathological classification. Results The patients with bladder transitional cell carcinoma showed a significantly elevated serum level of DcR3 （183.43±78.45 pg/m1） compared with the normal level （116.65±97.43 pg/m1, P0.05）. Conclusion In patients with bladder transitional cell carcinoma, a high serum level of DcR3 suggests a higher malignancy of the tumor.