pH监测阴性非糜烂性反流病患者食管体部蠕动中断长度与症状严重程度的关系

Association between the length of peristaltic break of esophageal body and the severity of the symptoms in patients with non-erosive reflux disease and negative pH monitoring

目的探讨pH监测阴性非糜烂性反流病（NERD）患者食管体部蠕动中断长度（LPB）与症状严重程度的相关性。方法纳入35例pH监测阴性NERD患者，同时选取10名健康对照者。采用食管高分辨率测压（HRM）检测两组的食管体部LPB，pH监测阴性NERD患者同时进行症状评分。两组间食管体部LPB比较采用t检验；Pearson相关分析研究pH监测阴性NERD患者食管体部LPB与症状严重程度的关系。结果pH监测阴性NERD患者食管体部平均LPB为（3．3±0．9）cm，长于健康对照者的（1．2±0．4）cm，差异有统计学意义（t=9．17，P〈0．01）。pH监测阴性NERD患者症状评分为21．6±7．8。pH监测阴性NERD患者食管体部LPB与症状评分呈正相关（r=0．894，P〈0．01）。结论食管体部蠕动中断是食管蠕动功能障碍的一种食管动力学表现，与NERD症状的发生相关。

Objective To explore the correlation between the length of peristaltic break （LPB） and the severity of the symptoms in patients with non-erosive reflux disease （NERD） and negative pH monitoring. Methods A total of 35 patients with NERD and negative pH monitoring were enrolled, and at same time 10 healthy individuals were selected as controls. The LPB of esophageal body of both groups was measured by high resolution manometry （HRM）. Meanwhile, the symptom of NERD patients with negative pH monitoring was scored. The LPB of esophageal body between the two groups was compared by t test. The correlation between the LPB and the severity of the symptoms in NERD patients with negative pH monitoring was analyzed by Pearson correlation analysis. Results The average LPB of esophageal body of NERD patients with negative pH monitoring was （3.3±0.9） cm, which was longer than that of healthy controls （（1. 2 ±0. 4） cm）, and the difference was statistically significant （t= 9.17,P〈0.01）. The symptom score of NERD patients with negative pH monitoring was 21.6 ± 7. 8. There was a positive correlation between the LPB and NERD symptom score （r= 0. 894, P〈0. 01）. Conclusion The LPB of esophageal body is a kind of expression of esophageal motility dysfunction, which is correlated with the symptom of NERD.