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肠道细菌和肠道天然免疫与炎症性肠病的关系 被引量：2

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摘要 我国近年来IBD患病率呈增长趋势。目前普遍认为IBD发病是环境、遗传和免疫等多因素相互作用的结果，其中肠道细菌和肠道天然免疫功能失调被认为是IBD的重要发病机制。
作者 王格 夏冰
机构地区 武汉大学中南医院消化内科湖北省肠病医学临床研究中心肠病湖北省重点实验室
出处 《中华消化杂志》 CAS CSCD 北大核心 2013年第12期882-884,共3页 Chinese Journal of Digestion
基金 国家自然科学基金（81070280）
关键词 肠道天然免疫 肠道细菌 炎症性肠病 免疫功能失调 发病机制 IBD 相互作用 患病率
分类号 R574 [医药卫生—消化系统]
  • 相关文献

参考文献22

  • 1Jiang L, Xia B, Li J, et al. Retrospective survey of 452 patients with inflammatory bowel disease in Wuhan city, central China. Inflamm Bowel Dis, 2006,12:212-217.
  • 2Molodecky NA, Soon IS, Rabi DM, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology, 2012,142:46-54.
  • 3Wehkamp J, Wang G, Kubler I, et al. The Paneth cell alpha defensin deficiency of ileal Crohn-s disease is linked to Wnt/Tcf-4. J Immunol, 2007 ,179: 3109-3118.
  • 4Ramasundara M, Leach ST, Lemberg DA,et al. Defensins and inflammation: the role of defensins in inflammatory bowel disease. J Gastroenterol Hepatol, 2009,24 : 202-208.
  • 5Beuling E, Baffour-Awuah NY, Stapleton KA, et al. GATA factors regulate proliferation, differentiation, and gene expression in small intestine of mature mice. Gastroenterology, 2011, 140 : 1219-1229.
  • 6Mowat AM, Bain CC. Mucosal macrophages in intestinal homeostasis and inflammation. J Innate Immun, 2011,3: 550-564.
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  • 8Marks DJ, Harbord MW, MacAllister R, et al. Defective acute inflammation in Crohn's disease: a clinical investigation. Lancet, 2006,367: 668-678.
  • 9Yadav PK, Chen C, Liu Z. Potential role of NK cells in the pathogenesis of inflammatory bowel disease. J Biomed Bioteehnol, 2011,2011:348530.
  • 10Heller F, Florian P, Bojarski C, et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology, 2005,129 : 550-564.

二级参考文献12

  • 1张以洋,智发朝,周殿元,姜泊,赖卓胜,张迎春,钟长青,龙靖华,徐迪辉,张奕.克罗恩病CARD15/NOD2基因突变的研究[J].中华消化杂志,2006,26(7):456-459. 被引量：15
  • 2龙靖华,智发朝,张迎春,张以洋,钟长青,姚国鹏,陈正彦,林勇,智佳,关婧.NOD2/CARD15基因突变与中国人克罗恩病相关性的研究[J].胃肠病学,2007,12(6):327-330. 被引量：20
  • 3钟长青,智发朝,王继德,龙靖华,张迎春.P268S突变型NOD2/CARD15真核表达载体的构建及其体外表达[J].胃肠病学,2007,12(6):331-334. 被引量：6
  • 4Buhner S, Buning C, Genschel J, et al. Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARDI5 3020insC mutation [J ]? Gut, 2006, 55(3): 342-7.
  • 5Hisamatsu T, Reinecker HC, Reinecker HC, et al. CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells[J]. Gastroenterology, 2003, 124(4): 993-1000.
  • 6Wehkamp J, Harder J, Weichenthal M, et al. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression[J ]. Gut, 2004, 53(11): 1658-64.
  • 7Massey DC, Parkes M. Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease [J ]. Autophagy, 2007, 3(6): 649-51.
  • 8Cummings JR, Cooney R, Pathan S, et al. Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene [J ]. Inflamm Bowel Dis, 2007, 13(8): 941-6.
  • 9Parkes M, Barrett JC, Prescott NJ, et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility [ J]. Natt Genet, 2007, 39(7): 813-5.
  • 10Hampe J, Franke A, Rosenstiel P, et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 [J]. Nat Genet, 2007, 39(2): 207-11.

共引文献8

同被引文献20

引证文献2

二级引证文献6

中华消化杂志
2013年 第12期

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