Dynamic changes of cardiovascular regulating factors in rats after aerobic exhaustive exercise

Objective To study the changes of cardiovascular regulating factors in rats during recovery of aerobic exhaustive exercise. Methods Sixty male Wistar rats were randomly divided into control group, 1 h-exercise group, 3 h-exercise group, exhausted group, 2 h-recovery group and 12 h-recovery group. The rats were killed at corresponding times for each group after an 8-week-long treadmill training, and the levels of NO, ET, ANP and TXB2 in plasma were measured in each group. Results NO/ET ratio of 1 h-exercise group was significantly higher than that in control group(P<0.01), while it was significantly decreased in 3 h-exercise group and exhausted group(P<0.05). ANP contents in rat plasma were significantly higher in 3 h-exercise group, exhausted group and 2 h-recovery group than that in control group(P<0.05 or P<0.01). The concentration of TXB2 in plasma was significantly increased in 3 h-exercise group, exhausted group and 2 h-recovery group(P<0.05). Conclusion Changes in cardiovascular regulating factors after exhaustive exercise may lead to deficiency of coronary circulation blood/oxygen supply, which may cause exerciseinduced fatigue.

Objective To study the changes of cardiovascular regulating factors in rats during recovery of aerobic exhaustive exercise. Methods Sixty male Wistar rats were randomly divided into control group, 1 h-exercise group, 3 h-exercise group, exhausted group, 2 h-recovery group and 12 h-recovery group. The rats were killed at corresponding times for each group after an 8-week-long treadmill training, and the levels of NO, El-, ANP and TXB2 in plasma were measured in each group. Results NO/ET ratio of 1 h-exercise group was significantly higher than that in control group （P〈0.01）, while it was significantly decreased in 3 h-exercise group and exhausted group （P〈0.05）. ANP contents in rat plasma were significantly higher in 3 h-exercise group, exhausted group and 2 h-recovery group than that in control group （P〈0.05 or P〈0.01）. The concentration of TXB2 in plasma was significantly increased in 3 h-exercise group, exhausted group and 2 h-recovery group （P〈0.05）. Conclusion Changes in cardiovascular regulating factors after exhaustive exercise may lead to deficiency of coronary circulation blood/oxygen supply, which may cause exercise- induced fatigue.