血小板在肿瘤转移中的作用

Role of platelets in tumor metastasis

侵袭和转移是导致癌症患者高死亡率的主要原因,机制复杂,其中血小板及其粘附分子发挥了重要作用。近来研究表明在肿瘤转移过程中血小板可保护肿瘤细胞免受循环系统的免疫清除,促进肿瘤细胞被脉管系统捕获进而导致进一步的组织损伤。本文结合国内外最新报道,对血小板在肿瘤转移中的作用进行综述。

Invasion and metastasis are the main causes of cancer mortality. Platelets and adhesion molecules play an impor- tant role in tumor invasion and metastasis. Recent studies have shown that platelets can protect tumor ceils from circulatory immune clearance and promote tumor cells arreste by the vasculature, leading to further tissue damage in the process of tumor metastasis. In this review, we summarize the role of platelets in tumor metastasis according to the latest reports.