2009-2011年某三甲医院鲍曼不动杆菌的耐药性分析

Analysis of drug resistance of Acinetobacter baumannii strains isolated from 2009 to 2011 in the third grade class A hospital

目的了解某三甲医院临床分离的鲍曼不动杆菌的分布及对各类抗菌药物的耐药性,以指导临床规范合理使用抗生素。方法收集常州市第一人民医院2009年1月至2011年12月临床分离的鲍曼不动杆菌,采用SPSS11.5统计软件统计分析鲍曼不动杆菌的检出率和耐药情况。结果2009-2011年共分离3 360株鲍曼不动杆菌,均占全院分离病原菌的前三位。最常见的分离部位为下呼吸道,主要来源于ICU、呼吸内科、神经外科和神经内科,该菌对亚胺培南、美罗培南和哌拉西林-他唑巴坦的耐药率在2009年分别是55.52%、56.53%和70.01%,2011年分别上升至79.70%、77.61%和79.76%,差异有统计学意义。结论鲍曼不动杆菌对多种抗菌药物耐药率明显增高,泛耐药鲍曼不动杆菌比例明显增加。应加强耐药性监测,规范抗菌素的使用,防止鲍曼不动杆菌的暴发流行。

Objective To investigate the distribution and drug resistance of Acinetobacter baumannii strains. Methods Clinical isolation and drug sensitivity test of A cine tob ac te r b aumannii in the First People＇s Hospital of Changzhou from Jan 2009 to Dec 2011 were retrospectively analyzed. Results A total of 3 360 A cinetobacter baumannii were isolated, which was one of the top three pathogenic bacteria from 2009 to 2011. Acinetobacter baumannii was primarily isolated from lower respiratory tracts of the patients main]y from department of intensive care unit （ICU）, departments of respiratory, neurosurgery and neurology. The drug resistance rate to imipenem, meropenem and piperacillin-tazobactam increased from 55.52%, 56.53% and 70.01% in 2009 to 79.70%, 77.61% and 79.76% in 2011, respectively. The difference was statistically significant. Conclusion There were obviously increasing tread in the drug resistant rates ofAcinetobacter baumannii from 2009 to 2011. It is difficult to clear Acinetobacter baumannii strains. Resistance surveillance of Acinetobacter bauma^nii, standard use of antibiotics, disinfection and isolation work should be strengthened to prevent epidemic outbreaks.