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多功能的胞内衔接蛋白syntenin

Syntenin as a Multifunctional Cellular Adaptor Protein
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摘要 Syntenin蛋白是在原核生物及真核生物中广泛存在的一类胞内衔接蛋白(adaptor proteins).Syntenin由N端结构域(N-terminal domain,NTD)、两个串联的PDZ结构域(postsynaptic density protein,disc large and zonula occludens,PDZ)和C端结构域(C-terminal domain,CTD)组成,在生物进化过程中相对保守.Syntenin蛋白的PDZ结构域可与不同膜受体C端的PDZ结合基序(PDZbinding motif,PBM)特异性结合,PDZ结构域结合受体的多样性导致了syntenin功能的多样性.本文综述了syntenin蛋白的发现与分布及其结构特征,对syntenin在肿瘤转移、细胞质膜蛋白组装、参与动物免疫等领域的研究成果进行了较为详细的综述,同时介绍了syntenin在参与动物胚胎发育调控、血管生成和轴突生长等方面的研究进展. Syntenin is one of the intracellular adaptor proteins that is genetically conserved among various animal species. It consists of two tandem PDZ （postsynaptic density protein, disc large and zonula occludens） domains, a N-terminal domain and a C-terminal domain. These PDZ domains bind to a wide range of target proteins that interacted with the C-terminal PDZ binding motifs to confer diverse and sophisticated functions, thus to influence tumor metastasis, immune regulation, intracellular signal transduction, and synaptic transmission to axonal growth, etc. The structure, distribution and the binding properties of syntenin, as well as the affected physiological functions are summarized in this review.
作者 王童 隋立乾 康翠洁
机构地区 教育部植物细胞工程与种质创新重点实验室
出处 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2013年第12期1097-1105,共9页 Chinese Journal of Biochemistry and Molecular Biology
基金 国家自然科学基金(No.31272689 No.30800839) 国家留学回国人员科研启动基金(No.2012-1707) 山东大学自主创新基金-交叉学科(No.2012-JC009)~~
关键词 SYNTENIN PDZ结构域 衔接蛋白 肿瘤转移 syntenin postsynaptic density protein disc large and zonula occludens （PDZ） domain adaptor proteins tumor metastasis
分类号 Q71 [生物学—分子生物学]
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参考文献60

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中国生物化学与分子生物学报
2013年 第12期

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