新型创面用凝胶体系的制备及性能研究

Preparation and Characteristics of a Novel Wound Gel

制备了用于创面愈合的壳聚糖(CS)-白芨胶(BSG)复合凝胶体系,并采用单因素试验考察了各因素对所得体系在37℃时胶凝时间的影响。优化得到CS浓度为2%、BSG浓度为1%和碳酸氢钠浓度为0.68 mol/L,所得制品胶凝时间为8.3 min。采用物性分析仪考察了CS和BSG浓度对凝胶性能的影响。结果优化处方具有较高的凝胶强度、黏附力、硬度、弹性和黏聚性。该凝胶体系的内部结构呈多孔性,且具有良好的持水性和吸水性。

The composite gel system based on chitosan （CS） and Bletilla striata gelatin （BSG） for wound healing was prepared and its formulation was optimized by single factor test with gelation time at 37 ℃ as the index. The gelation time of the optimal product with CS 2%, BSG 1% and sodium bicarbonate of 0.68 mol/L was 8.3 min. The effects of the concentrations of CS and BSG on gel properties determined by physical analyzer were investigated. The results showed that the gel strength, adhesion, hardness, elasticity and cohesiveness of the optimal product were relatively higher. The microstructure of this gel system was porous. Moreover, this system had good water binding capacity and water absorbability.