摘要
建立了气相色谱法测定甲巯咪唑的有关物质。采用Varian CP7595 CP-SIL 8CB AMIN型石英毛细管柱,程序升温,气化室温度150℃,氢火焰离子化检测器(FID)温度250℃。甲巯咪唑与起始原料、中间体以及降解产物分离良好。样品中的总杂质均小于0.1%。
A GC method was established for the determination of related substances in thiamazole. A Varian CP7595 CP-SIL 8CB AMIN silica capillary column was used, with programmed temperature, at the injection port temperature of 150 ℃ and the FID temperature of 250 ℃. There was good resolution of the related substances and thiamazole. The contents of total impurities in 3 batches of samples were all less than 0.1%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2013年第12期1272-1274,共3页
Chinese Journal of Pharmaceuticals