甲巯咪唑有关物质的GC法测定

Determination of Related Substances in Thiamazole by GC

建立了气相色谱法测定甲巯咪唑的有关物质。采用Varian CP7595 CP-SIL 8CB AMIN型石英毛细管柱,程序升温,气化室温度150℃,氢火焰离子化检测器(FID)温度250℃。甲巯咪唑与起始原料、中间体以及降解产物分离良好。样品中的总杂质均小于0.1%。

A GC method was established for the determination of related substances in thiamazole. A Varian CP7595 CP-SIL 8CB AMIN silica capillary column was used, with programmed temperature, at the injection port temperature of 150 ℃ and the FID temperature of 250 ℃. There was good resolution of the related substances and thiamazole. The contents of total impurities in 3 batches of samples were all less than 0.1%.