放线菌遗传重组育种研究进展

Progress on Genetic Recombination Breeding of Actinomycetes

放线菌是一类革兰阳性菌,能够产生丰富多样的天然产物。传统用于选育高产菌,或产新型天然产物的菌的主要方法是通过诱变育种。近年来,遗传重组技术的发展已有取代传统育种技术的趋势。本文综述了遗传重组技术应用于选育高产放线菌及产新型代谢产物放线菌的研究进展。

Actinomycetes are Gram-positive bacteria famous for their significant capacity for the production of natural products. Traditionally, researchers have developed many ways, which based on the mutagenesis and screen programmes, to screen the strains with high-output or with the capacity to produce novel natural products. Now, the development of the recombinant DNA technology facilitated the way of strain improvement. This review summarizes the progress of recombinant DNA technology applied in breeding of actinomycetes in improving natural products output and producing novel products.