血清趋化素与妊娠期肥胖及胰岛素抵抗的关系

Relationship between serum chemerin level and obesity,and insulin resistance during pregnancy

目的:探讨血清趋化素(chemerin)与妊娠期肥胖与胰岛素抵抗的关系。方法:测量其产前体重、空腹血糖(fasting plasma glucose,FPG)、空腹胰岛素(fasting insulin,FINS)等临床指标,ELISA检测血清中chemerin水平。结果:肥胖的GDM患者血清chemerin水平显著升高,表现出明显的胰岛素抵抗。血清chemerin水平与总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、C-反应蛋白(C-reactive protein,CRP)正相关。结论:chemerin通过影响血脂代谢,引起妊娠期肥胖及胰岛素抵抗。

Objective： To explore the relationship between serum chemerin level and obesity , and insulin resistance during preg- nancy. Methods： Thirty individuals with gestational diabetes mellitus （CDM） and 22 healthy control subjects were enrolled in this study. Prenatal weight, fasting plasma glucose （FPG） and fasting insulin （FINS） were measured , ehemerin levels were detected by ELISA.. Results： The serum levels of cbemerin significantly increased in obesity women with GDM, and showed obviously insulin resistance. The serum levels of chemerin were positively related with TC, TG and CRP. Conclusion： By influencing lipid metabolism, chemerin cause o- besity and insulin resistance durinz pregnancy.