早发型子痫前期预后因素的Logistic回归分析

Logistic analysis on the prognosis factors of early onset preeclampsia

目的：探讨早发型重度子病前期（EOSP）孕妇实施期待治疗过程中发生不良妊娠结局的危险因素。方法：回顾性分析2007年1月～2012年1月该院收治103例经期待治疗的EOSP孕妇的临床资料，按照有无孕妇严重并发症的发生分为不良妊娠结局组与对照组，分别比较两组患者的一般临床情况及各项检验指标。采用多因素Logistic回归分析不良妊娠结局的危险因素。结果：103例EOSP期待治疗中，28例孕妇出现严重并发症，发生率为28／103（27．18％）。经Logistic多因素回归分析，发病孕周（以30周为界）、分娩孕周（以32周为界）是孕妇严重并发症发生的独立危险因素。结论：EOSP期待治疗中需严密监护，发病孕周不足30周，分娩孕周小于32周孕妇严重并发症的发生显著增加。

Objective： To investigate the high risk factors in pregnancy women during the expectant management of early onset se- vere preeciampsia. Methods： Retrospective analysis was conducted on 103 pregnancy women with early onset severe preeelampsia, who un- derwent expectant management in our hospital. Patients were divided into maternal adverse outcome group and control group according to ma- jor maternal complications. The general clinical characters and laboratory findings were evaluated and compared between two groups respec- tively. Logistic regression analysis was used to explore the risk factors associated with maternal adverse outcome. Results： In total 103 preg- nancy women , there were 28 cases （27. 1% ） developed severe complications during expectant management. Logistic regression analysis showed that gestational age of onset （30 week gestation as the cutoff point） and terminal gestational age （32 week gestation as cutoff point） were independent high risk factors for maternal complications. Conclusion： Close monitoring is important during expectant management of early onset severe preeclampsia. The incidence of maternal complications are significantly increased when gestational age of onset less than 30 weeks and terminal gestational age less than 32 weeks.