OLF方案和EOF方案一线治疗晚期胃癌的疗效观察

目的比较OLF方案和EOF方案一线治疗晚期胃癌的临床疗效和毒副反应。方法选取从2008年5月-2012年11月间收治的48例晚期胃癌患者,分为OLF方案组(A组)与EOF方案组(B组),A组:奥沙利铂130 mg/m2d 1+亚叶酸钙(CF)75 mg/m2d 1-d 5+氟尿嘧啶(5-FU)500 mg/m2d 1-5;B组:表柔比星(EPI)50 mg/m2d 1+奥沙利铂130 mg/m2d 1+5-FU 500 mg/m2泵滴120 h。21 d为一个治疗周期,两周期后分析两种方案的疗效及毒副反应。结果两组方案有效率(CR+PR)无明显差异(P>0.05),A组骨髓抑制、胃肠道反应组明显轻于B组(P<0.05),其他肝肾功能损害、神经毒性、脱发等,两组无明显差异(P>0.05)。结论 OLF方案安全高效,在化疗毒副反应方面更易为患者接受。

Objective To compare the efficacy and toxicity of OLF regimen and ECF regimen in the treatment on patients with advanced gastric carcinoma. Methods 48 cases with advanced gastric cancer were selected in Nantong Tumor Hospital during May 2008 to November 2012, which were devided into 2 groups . The patients in group A（OLF regimen） recieved intravenous infusion of oxaliplatin 130 mg/m2 at day I, leucovorin （CF） 75 mg/m2 at days 1-5, and fluorouracil （5- FU） 500 mg/m2 at days 1-5. The patients in group B（EOF regimen） recieved intravenous infusion epirubicin （EPI） 50 mg/m2 at day i, oxaliplatin 130 mg/m2 at day I, and bolus injection of 5-Fu 500 mg/m2 at day 1 in 120 h. each treatment cycle also lasted 21 days, and therapeutic effec and toxicity between two groups were analysised after 2 cycles. Results There was no significant diffrence of the overall response rate （PR ＋ CR） between 2 groups （P〉 0.05）. Bone marrow suppression and gastrointestinal reactions of group A were significantly lighter than which of group B（P〈0.05 ）. And there was no significant diffrence in liver failure, kidney dysfunction, neurotoxicity, and alopecia between 2 groups （P〉0.05）. Conclusion OLF regimen was safe and efficient in treatment on patiens with gastric carcinoma, and was easier for patients to accept in terms of chemotherapy toxicities.