Mdm2与p53在新疆哈萨克族食管鳞癌中的表达及作用

Expression and clinical significance of Mdm2 and p53 in Xinjiang Kazaks' esophageal squamous cell carcinoma

目的探讨Mdm2与p53在新疆哈萨克族食管鳞癌中的表达及临床意义。方法应用RT-PCR法检测48例新疆哈萨克族食管鳞癌组织及其配对的正常远端无癌组织中Mdm2和p53的表达,分析其表达与肿瘤分化、TNM分期、临床分期、淋巴结转移的关系。结果新疆哈萨克族食管鳞癌组织中Mdm2与p53的阳性表达率(68.75%、77.1%)与癌旁正常组织(66.7%、72.9%)差异无统计学意义(P>0.05)。p53的表达随肿瘤分期进展呈降低趋势,其差异有统计学意义(P<0.05)。Mdm2阳性表达强度与p53的阳性表达呈正相关(r=0.809,P<0.05)。结论 Mdm2的高表达和p53的低表达伴随新疆哈萨克族食管鳞癌的发生,二者在新疆哈萨克族食管鳞癌的发生发展中起协同作用。

Objective To investigate the expression of Mdm2 and p53 in Xinjiang Kazaks＇ esophageal squa- mous cell carcinoma （ESCC） and analyze its clinicopathological significance. Methods A total of 48 Xin- jiang Kazaks ESCC specimens were involved in the study. Matched normal esophageal mucosal tissues were used as controls. The expression of Mdm2 and p53 was detected by RT-PCR. The correlation of Mdm2 and p53 with the development and progression of ESCC was then analyzed. Results The positive expression rates of Mdm2 and p53 （68.75 %, 77.1%） had no significant difference with those in normal esophageal mu- cosal tissues （66.7%,72.9%） （P =0.827,P ：0.637,P ~0.05）. With the development of ESCC, the ex- pression of p53 decreased and it had significant difference （P = 0.048,P %0.05）.The expression of Mdm2 was positively correlated with that of p53 （r =0.809,P =0.000,P〈0.05）. Conclusion The high expres- sion of Mdm2 and low expression of p53 work in the development of ESCC.