TF方案和FOLFOX6方案治疗晚期胃癌的疗效观察

The efficacy observation of TF regimen and FOLFOX6 regimen on advanced gastric cancer

目的比较TF方案和FOLFOX6方案治疗晚期胃癌的疗效及不良反应。方法选择新疆医科大学附属肿瘤医院消化内科收住的54例经病理确诊的晚期胃癌患者,A组采用TF化疗,B组采用FOLFOX6方案,对两组的近期疗效、生活质量改善情况、总生存期、无疾病进展时间、不良反应进行比较。结果 A组有效率为46.40%,无疾病进展时间为5.5个月,中位生存时间为8.0个月;B组有效率为46.20%,无疾病进展时间为5.5个月,中位生存时间为8.5个月,两组差异均无计学意义。A组和B组的生活质量改善率分别为64.3%和30.80%,差异有统计学意义;两组不良反应均表现为消化道反应及骨髓抑制方面,其中以恶心、呕吐最常见,其次白细胞下降及贫血。结论 TF方案和FOLFOX6方案治疗晚期胃癌近期疗效均较好,在不良反应以及生活质量改善情况方面,TF方案均优于FOLFOX6方案,具有更好的耐受性。

Objective To compare the efficacy and toxicity between TF regimen and FOLFOX6 regimen in advanced gastric carcinoma. Methods 54 cases with advanced gastric cancer confirmed by pathology of De- partment of Gastroenterology of The Affiliated Tumor Hospital in Xinjiang Medical University were se- lected for the study. Group A was treated with TF regimen and the group B treated with FOLFOX6 regi- men. Then the efficacy,Progression Free Survival （PFS）, overall survival （OS） ,improvement of QOL and toxicity from the two regimens were compared and analyzed. Results In group A, the response rate （RR） was 46.40%, the median survival （RR） was 46.20~/0, the median survival time was 8.50 months; the me- dian PFS of both groups was 5.50 months, difference was not statistically significant of two groups. The improvement rate of QOL of A and B were 64.30~./00 and 30.80~//0, difference was statistically significant. Two adverse reactions were manifested as gastrointestinal reactions and bone marrow suppression, in which nausea, vomiting were the most common phenomena, followed by leukopenia and anemia. Conclu- sion Both TF and FOLFOX6 regimens were effective in treating advanced gastric cancer patients. TF reg- imen is better than FOLFOX6 regimen on the improvement of QOL and toxicities tolerance.