糖尿病及其高危人群血清维生素D的现况调查

Serum vitamin D current status in diabetic mellitus patients and the high risk group

目的探讨糖尿病及其高危人群血清维生素D的现况及相关因素。方法对水磨沟区居民进行整群抽样调查,筛选出糖尿病高危人群及糖尿病患者,检测其血糖、胰岛素、血清25(OH)D3,选取数据完整的555例。分别根据年龄、性别、族别分组,比较各调查指标的变化。并对影响维生素D浓度的危险因素行非条件Logistic回归分析。结果血清25(OH)D3水平为38.0～110.7nmol/L;青壮年和中老年、男性和女性、维吾尔族和汉族血清25(OH)D3差异均无统计学意义;非条件Logistic回归分析提示,不吃动物肝脏、不穿短袖、不喝牛奶为导致维生素D不足的危险因素,胰岛素抵抗为避免维生素D不足的保护因素。结论该糖尿病及其高危人群中维生素D不足的情况较严重,年龄、性别、民族对血清维生素D水平均无明显影响;经常进食动物肝脏、每天喝牛奶、夏天穿短袖可提高血清维生素D的含量,胰岛素抵抗为避免维生素D不足的保护因素。

Objective To investigate current status and influence factors of serum vitamin D in the people of diabetic mellitus and the high risk group. Methods The cluster samples from the district of Shuimogou residents are divided into the high risk group and patients of diabetic mellitus; plasma glucose, insulin, and serum 25（OH）D3, of 555 subjects with complete data were analyzed to compare each indicator of epi- demiologic survey in terms of age, sex, and nation; Risk factors of affecting the level of serum vitamin D had been done Logistic regression analysis. Results Serum vitamin Dr s concentration of the group is be- tween 38.0 nmmol/L and 110.7 nmol/L.There were no statistical significant differences between the young and the old, male and female, the Uygur and Han population respectively in the analysis of the level of se- rum 25（OH）D3 ; Not eating liver.not wearing short sleeve in summer, not drinking milk are risk factors to lead to insufficiency of vitamin D, and Insulin resistance can avoid the lack of vitamin D. Conclusion The degree of insufficiency of vitamin D in the people is very severity. The level of serum vitamin D is not been affected by age, sex, nation in the group; Often eating liver, wearing short sleeve in summer, drink- ing milk every day can increase the level of vitamin D; In this group, Insulin resistance can avoid the lack of vitamin D.