摘要
目的测定阿齐沙坦的油水分配系数。方法配制不同pH值的磷酸盐缓冲液,以正辛醇-磷酸盐缓冲液作为分散系统,摇瓶法作为测定方法,照紫外-可见分光光度法(《中国药典》2010年版附录ⅣA)进行测定。通过阿齐沙坦分配平衡后在油相(正辛醇)和水相的浓度比,计算油水分配系数。结果在正辛醇-磷酸盐缓冲液体系中,pH=3.0时阿齐沙坦的油水分配系数为3.78,pH=7.0时阿齐沙坦的油水分配系数为0.30。结论应用摇瓶-紫外分光光度法,能够准确测定阿齐沙坦的油水分配系数,并由此推测其体内过程。
Objective To determine the oil-water partition coefficient of Azilsartan.Methods A shake flask-ultraviolet spectrophotometry method was applied to determining the oil-water partition coefficient of Azilsartan in n-octanol-buffer solution systems with different pH values.Results The LgP of Azilsartan under pH 3.0 was 3.78 and pH 7.0 was 0.30.Conclusion The shake flask-ultraviolet spectrophotometry method can be used to determine the oil-water partition coefficient of Azilsartan,and help to predict the in vivo process.
出处
《药物评价研究》
CAS
2013年第6期452-454,共3页
Drug Evaluation Research
关键词
阿齐沙坦
油水分配系数
紫外分光光度法
Azilsartan
oil-water partition coefficient
ultraviolet spectrophotometry
