多糖化学结构修饰方法的研究进展

Research progress in structural modification of polysaccharide

多糖是一类重要的生物大分子物质,具有抗肿瘤、抗病毒、抗氧化、免疫活性调节等生物活性。多糖的生物活性与其结构有直接关系,因而对多糖结构通过适当的方法进行修饰是目前多糖领域研究的重要方向之一。简要地阐述多糖的化学修饰方法(包括硫酸化、羧甲基化、乙酰化和磷酸化等)研究进展,以及修饰后对生物活性的影响,以期为新药发现提供依据。

Polysaccharide is an important class of biological macromolecules.It has a variety of biological activity,such as antitumor,antivirus,anti-oxidation,immune activity regulation,and so on.The biological activity of polysaccharide has a direct relationship with its structure.Thus the structural modification of polysaccharide by an appropriate method is one of the important directions of research in the field of polysaccharides.This article systematically elaborated the structural modification methods and research progress on the polysaccharide including chemical,biological,and physical methods,as well as the impact on the biological activity.