12例左氧氟沙星致心血管不良反应分析

Analysis on 12 cases of cardiovascular adverse reactions induced by Levofloxacin

目的探讨左氧氟沙星致心血管不良反应的一般规律与特点。方法对福建省长乐市医院2010年1月—2013年3月上报的12例左氧氟沙星所致的心血管不良反应报告表进行统计、分析。结果左氧氟沙星致心血管不良反应在老年患者发生率较高,多在用药2h内发生。临床表现复杂多样,主要表现为心悸和心脏不适,严重者可出现心脏传导阻滞。结论临床上应重视左氧氟沙星的心血管不良反应,坚持合理用药。

Objective To explore the cardiovascular adverse reactions caused by the general rules and characteristics of Levofloxacin.Methods Twelve cases of cardiovascular adverse reactions reports in Fujian Changle Hospital from January 2010 to March 2013were statistically analyzed.Results Cardiovascular adverse reactions caused by Levofloxacin were mostly happened in the elderly patients 2h after the medication.There were complex and diverse clinical manifestations,such as heart palpitations and cardiac discomfort,and even serious heart block.Conclusion The clinical application of Levofloxacin should be seriously monitored,in order to reduce the occurrence of cardiovascular adverse reactions.