FAT4基因功能性单核苷酸多态性和中国江苏人群胃癌易感性相关

Nonsynonymous polymorphisms in FAT4 gene are associated with the risk of gastric cancer in a Jiangsu population

目的：探讨FAT4基因单核苷酸多态性与江苏人群胃癌遗传易感性的关系。方法：采用人群为基础的病例对照研究对来自江苏的783例经组织病理学确诊的胃癌新发病例和按照性别年龄匹配的855例健康对照,利用实时荧光定量PCR（real-time PCR）方法对FAT4基因上非同义氨基酸多态性位点进行基因分型,比较各位点不同基因型与胃癌发病风险的关系。结果：利用Logistic回归模型在相加模型中进行了分析的结果显示,在调整性别。年龄。吸烟和饮酒等因素后,携带rs1039808 A等位基因的个体胃癌发病风险显著低于携带野生纯合子（GG）的个体（OR = 0.74,95%CI：0.62-0.88,P = 0.001）。分层分析显示,在各亚组间rs1039808不同基因型与胃癌发病风险的关联强度没有显著差异。结论：FAT4基因单核苷酸多态性rs1039808 A等位基因能显著降低胃癌发病风险。

Objective：To investigate the association between nonsynonymous polymorphisms （rs1039808,rs12508222,rs1567047 and rs1014867） in FAT4 gene and the risk of gastric cancer. Methods：A case-control study of 783 gastric cancer cases and 855 controls was conducted in a Chinese population of Jiangsu Province using the TaqMan allelic discrimination assay on the ABI 7900 system. Results：We found that A allele of rs1039808 （Ala807Val） was significantly associated with a decreased risk of gastric cancer risk in additive model after adjusted by age,sex,smoking and drinking status （OR = 0.74,95%CI：0.62~0.88,P = 0.001）. Similar association strengths were shown between all subgroups for rs1039808（P〉0.05 for heterogeneity test）. Conclusion：These findings indicate that the nonsynonymous variants rs1039808 （Ala807Val） of FAT4 may contribute to gastric cancer susceptibility in a Chinese population of Jiangsu Province.