FGR母体血及脐血中IGF-1水平与胎盘病理变化的关系

Relationship between IGF-1 and placental pathologic changes in maternal and umbilical blood with fetal growth restriction

目的 了解胎儿生长受限（FGR）时母体血及脐血中胰岛素样生长因子-1（IGF-1）水平与胎盘病理变化的关系,以进一步探讨FGR的发病机制.方法 对40例妊娠合并胎儿生长受限组（FGR组）及40例正常孕妇组（对照组）,采取母体外周静脉血及脐血,测定其中IGF-1水平;光镜观察2组胎盘绒毛发育、末梢绒毛内毛细血管个数、血管占绒毛面积、绒毛面密度.结果 与对照组相比,FGR时母体血及脐血中IGF-1水平降低,差异有统计学意义（P〈0.05）; FGR组胎盘病理变化与对照组相比,差异有显著性（P〈0.05）.结论 FGR时,母血及脐血中IGF-1水平降低,导致胎盘微循环形成障碍,胎盘血流灌注减少,引起缺血缺氧,胎盘病理变化明显.

Objective To study the relationship between the insulin like growth factor - 1 （ IGF - 1 ） and placental pathologic changes in maternal and umbilical blood with fetal growth restriction. Methods Maternal peripheral venous blood and umbilical blood were collected from 40 pregnant women with fetal growth restriction （FGR group ） and 40 healthy pregnant women （ control group） to detect the level of IGF - 1. Then, the placenta were studied after delivery un- der a light microscopy. Results In FGR group, the level of IGF - 1 and placental pathological changes in the maternal and umbilical blood were statistically different from those in the control group （ P 〈 0.05 ）. Conclusion A lower level of IGF - 1 was detected in the maternal and umbilical blood, resulting in fetal -placenta microcirculation disorder, reduced placental blood perfusion, hypoxia and ischemia, and obvious placenta pathological changes.