不同性别颈动脉粥样硬化患者幽门螺杆菌感染与血脂的关系

Relationship between helicobacter pylori infection and blood lipid among atherosclerosis sufferers with different genders

目的探讨颈动脉粥样硬化患者幽门螺杆菌(Hp)感染与血脂的关系。方法根据13C-尿素呼气试验结果,将553例颈动脉粥样硬化患者分为Hp阳性组、Hp阴性组,按男、女分别比较两组体重指数(BMI)、收缩压(SBP)、舒张压(DBP)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、脂蛋白(a)[Lp(a)]、空腹血糖(FBG)、血尿酸(UA)、超敏CRP(hs-CRP)的差异。结果不管是男性还是女性颈动脉粥样硬化患者,Hp阳性组的TC、Lp(a)均高于Hp阴性组,Hp阳性组的HDL-C低于Hp阴性组,但差异无统计学意义。只有男性颈动脉粥样硬化患者Hp阳性组的LDL-C显著高于Hp阴性组(P<0.05)。结论男性颈动脉粥样硬化患者Hp感染可能与LDL-C有关。

Objective To explore the relationship between helicobacter pylori infection and blood lipid among carotid atherosclerosis suf- ferers.Methods 553 carotid atherosclerosis sufferers were divided into two groups according to13C-urea breath test results：positive heli- cobacter pylori group and negative helicobacter pylori group.Body mass index（BMI）,systolic blood pressure（SBP）,diastolic blood pressure（DBP）,triglycerides（TG）,total cholesterol（TC）,low density lipoprotein cholesterol（LDL-C）,high density lipoprotein cholesterol（HDL-C）, lipoprotein（a） [Lp（a）],fasting blood glucose（FBG）,serum urine acid（UA） and high-sensitivity CRP（hs-CRP） were compared between the two groups by gender differences.Results For both male and female atherosclerosis sufferers,the levels of TC and Lp（a） in the positive he- licobacter pylori group were higher than those in the negative helicobacter pylori group,while the level of HDL-C in the positive helicobac- ter pylori group was lower than that in the negative helicobacter pylori group,the differences were not of statistical significance（P ＆gt;0.05）. Only the level of LDL-C of male carotid atherosclerosis sufferers in the positive helicobacter pylori group was significantly higher than that of male carotid atherosclerosis sufferers in negative helicobacter pylori group（P ＆lt;0.05）.Conclusion Helicobacter pylori infection in male carotid atherosclerosis sufferers may relate to the level of LDL-C.