HBV感染者血清CG检测的临床意义

Singnificance of serum CG Detection in patients with HBV infection

为了研究临床肝功能检验结果正常的乙型肝炎病毒(HBV)感染者血清甘胆酸(CG)水平及其分布规律,以探讨其肝细胞受损情况及其临床应用价值,采用放射免疫分析技术(RIA),将579例肝功能检验正常的HBv感染者分工～Ⅶ种模式进行血清CG测定,并与69例健康人血清CG含量对比。结果显示,Ⅰ～Ⅵ模式HBV感染组与健康组比较均显著增高,以有病毒复制和传染性强者最为明显。标明在HBV感染者中普遍存在着临床肝功能检验反映不出的肝细胞实质性损伤的微观变化,RIA测定血清CG含量是反映这一微观变化的灵敏指标,并对判断肝细胞恢复情况和疗效观察有重要临床意义。

In order to study the serum CG level and its distribution regularity in HBV infected patients with normal liver function, and to investigate the condition of liver cell injury and its value for clinical application, the serum CG of 597 cases of HBV infected patients with normal liver function divided into Ⅰ - Ⅵ patterns was detected by RIA and compared with the serum CG levels of 69 normal cases (control), The results showed that the serum CG levels of HBV infection groups in Ⅰ - Ⅵ patterns was significantly higher than that of normal groups,especially in the patients with virus copy and strong infection. It is proved that there were microchanges of live cell injury in patients with HBV infection whose liver function can not reflect the microchanges. Serum CG detection by RIA is a sensitive methods for these microchanges, and it has clinical significance for liver recruit and treatment effect observation.