福建省人微小病毒B19感染血清流行病学的研究

Serological Investigation on Human Parvovirus B19 Infections in Fujian

[目的 ]了解福建省人群血清中人微小病毒 B19的感染状况及其引起的疾病谱分布特点。 [方法 ]应用EL ISA方法检测血清中 Ig G、Ig M抗体。 [结果 ]检查由 B19病毒感染引起的相关症状疾病血清 B19- Ig G抗体阳性率48.8% ,非 B19病毒感染疾病病人血清阳性率 2 0 .7% ,两者比较χ2 =6 .36 ,P<0 .0 5。相关症状中以皮肤红斑阳性率最高 ,其次为再生障碍性贫血、关节炎、流产、畸胎等疾病。正常供血员阳性率 38.1%。检查人微小病毒 B19感染引起相关症状病人血清 Ig M抗体共 172份 ,仅从关节疼痛的患者中检出 1例阳性 ,另外有 7份可疑阳性 ;检查供血员血清 5 6份 ,可疑阳性 2份。 [结论 ]证实福建省人群中存在人微小病毒 B19感染 ,沿海与山区在地区分布上无差异 ,以皮肤红斑、再生障碍性贫血、关节炎等疾病中检出为多 ,在正常供血员血清中亦检出

Objective] To investigate the infections with parvovirus B19(B19) in related patients and health blood donors, and their characterize of the diseases distribution [Methods] To test B19 IgG and B19 IgM antibodies in serum by ELISA (MRL,DIAGNOSTICS) [Results] The positive rate of B19 IgG from patients was 48 8 % (39/80) and 20 7 % (6/29) with other diseases(χ 2=6 36, P<0 05) The positive rate of skin erythema was higher than aplastic anemia, rheumatoid arthritis, abnormal abortion and congenital abnormalities etc The positive rate of health blood donors was 38 1%(48/126) In 172 patients associated infections for B19 IgM testing, only one patient with rheumatoid arthritis was positive and another 7 patients were undetermined There were 2 cases undetermined in 56 health blood donors [Conclusion] There exist a serological evidence of parvovirus B19 infections and no significant difference between coastal and mountainous areas in Fujian The diseases associated B19 are skin erythema , aplastic anemia and rheumatoid arthritis B19 IgG antibody can be detected in health blood donors