复方聚维酮碘片及其主要成分的镇痛作用研究

The analgesic effects of Compound polyvidone iodine tablet and its active components in mice

目的 评价复方聚维酮碘片 (CPI)的镇痛作用 ,分析其主要成分对镇痛效应的影响。方法 小鼠尾部涂抹或灌胃给药 ,采用光辐射热甩尾法和醋酸扭体法 ,观察CPI、聚维酮碘 (PI)和双氯芬酸钠 (DS)的镇痛作用。结果CPI鼠尾局部涂抹给药无明显镇痛作用。灌胃给药 ,CPI和DS对小鼠光辐射热甩尾反应和醋酸扭体反应均呈剂量相关性镇痛作用。PI灌胃给药对小鼠光辐射热甩尾反应无抑制作用。结论 CPI对热和化学刺激引起的疼痛反应有明显镇痛作用。CPI的镇痛作用主要由DS产生。

Objective: To evaluate the analgesic effects of Compound polyvidone iodine tablet (CPI) and study the influence of CPI chief active components, polyvidone iodine (PI) and diclofenac sodium (DS), on the analgesic effects Methods: The analgesic effects of CPI, PI and DS were observed by acetic acid inducing writhing model and light radiant heat inducing tail flick latency in mice Results: When CPI and DS administered intragastrically, the writhing reaction induced by acetic acid was inhibited and the tail flick latency induced by radiant heat rose significantly in mice And the analgesic effects were dependent on the dosage The analgesic effects were not observed when CPI was painted locally on the tail and PI administered intragastrically in mice Conclusion: The pain reaction induced by radiant heat and chemical stimulus can be significantly relieved by CPI The analgesic effects of CPI are produced by its active component DS