消渴舒的药效学及毒理学研究

The study of the pharmocodynamics and toxicology of Xiaokeshu

按降糖药物的筛选规程[1] ;通过药效学试验证明消渴舒每日 15g/Kg、7 5g/Kg的剂量灌胃给药后 ,对正常动物血糖值有明显降低作用 (P <0 0 5 ) ,对肾上腺素引起的高血糖小白鼠有明显抑制作用 ,与空白对照组比较有显著性差异 (P <0 0 1) ,对四氧嘧啶引起糖尿病的动物有明显减轻作用 ,用药前后血糖有显著变化 ,连续给大鼠灌服 30d对实验性高血脂症的形成与高血脂模型组比较 ,血清总胆固醇 (TC)、血清甘油三脂 (TG)均有显著差异 (P<0 0 0 1)。毒理学实验表明 ,相当于临床用量的 5 0倍连续给药 90d无毒副反应 ,大鼠的血液生化指标、病理组织学检查与空白组比较无异常 ,提示该药临床应用是安全有效的。

Objective: To research into the pharmacodynmics and tolicology of Xiaokeshu. Methods: According to gucose decreasing drug selecting rule [1] , Xiaokeshe was used for normal animals, diabetes animals and hypercholesterolemia rats in the dose of 15 g/kg; 7.5 g/kg daily intragastricall. Results: Xiaokeshu decreased the normal animal serum glucose and inhibited the high serum glucose induced by the adrenaline significantly compared to the control group. The serum glucose in diabetes animals induced by tetraoxy primidline was changed significantly after taking the drug. There were significant differences between the experimental developing of hypercholesterolemia and hypercholesterolemia model group in the friglyceride and total cholesteral 30 days after taking the drug (P<0 001). The toxicology test demonstrated there was no side or toxisity eftect affer 90 days in the dose of 50 fold of clinical dose intragstrically, and no significant difference in serum chemical index and pathohistolosical examination compared to the control group. Conclusion: The druy is safe and effectiue in clinical application.