精神分裂症患者血浆精氨酸加压素测定

Plasma arginine vasopressin (AVP) level in acute and chronic schizophrenia

目的 :探讨急、慢性精神分裂症患者血浆精氨酸加压素 (AVP)水平的变化。 方法 :采用放射免疫法测定 141例精神分裂症患者 (急性 76例 ,慢性 6 5例 )及 2 8例正常对照者的血浆 AVP水平。 结果 :急、慢性精神分裂症患者血浆 AVP水平均较对照者低 ,差异非常显著 ;慢性患者血浆AVP水平降低较急性患者尤为显著。 结论 :精神分裂症患者存在 AVP代谢异常的现象 ,且慢性患者较急性患者更明显。

Objective:To explore the changes of plasma AVP level in patients with acute and chronic patients. Method:Plasma AVP level was determined by the method of radioimmunoassay in 141 schizophrenic patients (76 acute,65 chronic) and 28 normal controls. Results:Plasma AVP levels were significant lower in acute and chronic schizophrenia than in controls, especially in chronic patients. Conclusion:The results suggest that there is abnormal metabolism of plasma AVP in schizophrenia,in addition,there is significant difference between chronic and acute patients.