血红素氧合酶-1和谷胱甘肽转移酶与脑动脉硬化程度的关系

Study on the relationship between heme oxygenase-1 and glutathione S-transferase and cerebral atherosclerosis

目的探讨血红素氧合酶-1（HO-1）和谷胱甘肽转移酶（GST）与脑动脉粥样硬化程度的关系。方法应用颈部血管彩超、经颅多普勒超声检查（TCD）及磁共振血管成像（MRA）或数字减影血管造影（DSA）进行血管评估，将脑动脉粥样硬化程度分为轻度、中度、重度，采用酶联免疫吸附法（ELISA）法检测血清HO-1和GST水平。结果病例组和对照组比较，年龄、高血压、脑梗死、尿酸、血清HO-1水平方面差异均有统计学意义（P=0．041，0．008，0．000，0．036，0．001）；且重度脑动脉硬化患者血清HO-1水平比轻度、中度脑动脉硬化患者低（P=0．000，0．002）。Logistic回归分析示，HO-1水平与脑动脉硬化病变程度有关（P=0．000）。结论HO-1与脑动脉粥样硬化病变程度可能存在某种内在的联系。

Objective To investigate the relationship between heme oxygenase-1 （HO-1）, gluta- thione S-transferase （GST） and cerebral atherosclerosis. Methods Cerebralvascular status was assessed with color flow Doppler sonography, transcranial Doppler （TCD）, magnetic resonance angiography （MRA） or/and digital subtraction angiography （DSA） in patients with cerebral athel^osclerosis （mild, moderate, and severity）. Serum HO-1 and GST were measured with enzyme-linked immunosorhent assay （ELISA）. Results In comparison between case and control groups, there was significant difference in age, hyperten- sion, cerebral infarction, uric acid, and HO-1 （P =0.041, 0.008, 0.000, 0.036, and 0.001）. The level of serum HO-1 in the severe atherosclerosis was lower than that in the mild and moderate atherosclero- sis （ P = 0. 000 and 0. 002）. Logistic regression was used to find the association of HO-1 and the degree of cerebral atheroselerosis （ P = 0. 000）. Conclusions HO-1 might be related to cerebral atherosclerosis.