摘要
目的探讨血红素氧合酶-1(HO-1)和谷胱甘肽转移酶(GST)与脑动脉粥样硬化程度的关系。方法应用颈部血管彩超、经颅多普勒超声检查(TCD)及磁共振血管成像(MRA)或数字减影血管造影(DSA)进行血管评估,将脑动脉粥样硬化程度分为轻度、中度、重度,采用酶联免疫吸附法(ELISA)法检测血清HO-1和GST水平。结果病例组和对照组比较,年龄、高血压、脑梗死、尿酸、血清HO-1水平方面差异均有统计学意义(P=0.041,0.008,0.000,0.036,0.001);且重度脑动脉硬化患者血清HO-1水平比轻度、中度脑动脉硬化患者低(P=0.000,0.002)。Logistic回归分析示,HO-1水平与脑动脉硬化病变程度有关(P=0.000)。结论HO-1与脑动脉粥样硬化病变程度可能存在某种内在的联系。
Objective To investigate the relationship between heme oxygenase-1 (HO-1), gluta- thione S-transferase (GST) and cerebral atherosclerosis. Methods Cerebralvascular status was assessed with color flow Doppler sonography, transcranial Doppler (TCD), magnetic resonance angiography (MRA) or/and digital subtraction angiography (DSA) in patients with cerebral athel^osclerosis (mild, moderate, and severity). Serum HO-1 and GST were measured with enzyme-linked immunosorhent assay (ELISA). Results In comparison between case and control groups, there was significant difference in age, hyperten- sion, cerebral infarction, uric acid, and HO-1 (P =0.041, 0.008, 0.000, 0.036, and 0.001). The level of serum HO-1 in the severe atherosclerosis was lower than that in the mild and moderate atherosclero- sis ( P = 0. 000 and 0. 002). Logistic regression was used to find the association of HO-1 and the degree of cerebral atheroselerosis ( P = 0. 000). Conclusions HO-1 might be related to cerebral atherosclerosis.
出处
《中国医师杂志》
CAS
2013年第11期1458-1461,共4页
Journal of Chinese Physician
基金
基金项目:长沙市科技局基金项目(K1104059)