山东沿海地区2型糖尿病血管并发症患病率调查及危险因素研究

PREVALENCE OF VASCULAR COMPLICATIONS AND ITS ASSOCIATION WITH RISK FACTORS IN TYPE 2 DIABETES PATIENTS IN THE SEABOARD OF SHANDONG PROVINCE

目的: 了解山东沿海地区2 型糖尿病血管并发症发生情况并探讨其危险因素。方法:参照1980 年京津地区糖尿病血管并发症研究方案, 1997 年～1998 年对山东沿海地区408 例年龄35 岁～55 岁、病程0 ～≥14 a 的2 型糖尿病患者( 男200 例、女208 例) 进行有关临床、生化指标、眼科、心电图( 明尼苏达编码) 检查。结果: 血管并发症患病率依次为: 视网膜病变(DR) 47-8 % 、高血压( HT) 43-1 % 、肾脏病变(DN) 41-9 % 、冠心病(CHD)24-0 % 、下肢血管病变(PVD) 8-1 % 、脑血管病变(CVD) 7-4 % 。Logistic 逐步回归分析显示年龄和病程分别是CHD、CVD、PVD 和DR、DN 的危险因素; HT 是大小血管并发症共同的危险因素; 糖化血红蛋白升高是DR 的危险因素; 甘油三酯和纤维蛋白原升高是DN 的危险因素。结论: 积极控制血压、血糖,

Objective:To determine the prevalence of diabetic vascular complications and its risk factors in the seaboard of Shandong Province.Methods:According to the protocol of Beijing Tianjin Area Diabetes Vascular Diseases Study,a set of examinations included clinic history, biochemical tests,ophthalmoscopy and electrocardiogram(by using the Minnesota code) were carried out in 408 type 2 diabetes patients(aged 35 to 55 years,duration 0 ≥14 years).Results:Of these patients,47 8% had complicated with retinopathy(DR),43 1% with hypertension(HT),41 9% with nephropathy(DN),24 0% with coronary heart disease(CHD),8 1% with peripheral vascular disease(PVD),and 7 4% with cerebrovascular disease(CVD).The logistics regression analysis showed that the significant risk factors included advanced age for CHD,CVD,PVD and duration of diabetes for DR, DN respectively.HT was the common risk factors for micro and macrovascular complications.Other identified risk factors were high HbA 1 c for DR,high triglyceride and high fibrinogen for DN.Conclusion:Close control and correction of these abnormalities were important to prevent diabetic vascular complications.