摘要
目的 进一步探讨血清前列腺特异性抗原(PSA)与前列腺增生症(BPH)之间的关系及PSA 在BPH诊断中的意义。方法 对有排尿障碍并经病理检查证实的BPH患者58例进行了分析研究。结果 72.41％的患者血清 PSA值<10ng/ml,且各年龄段 PSA值均略高于正常参考范围,但与年龄无相关关系(P>0.05)。44例开放切除术标本每克增生组织产生的 PSA值为 0.21ng/ml,60.09％的腺体重量<50g,PSA 与腺体重量的增加有一定的正相关关系(P<0.05)。本组病理检查除BPH 外,还有48.82％患者伴发有癌前病变。结论 BPH 病例血清PSA值虽略有增高,但由于多种因素的干扰,PSA失去临床诊断价值。PSA 的实际意义在于鉴别和早期发现局限性癌,与癌前病变无相关关系。
Purpese To further study the relationship between serum PSA and BPH as well as theSignificance of PSA in the diagnosis of BPH .Methods 58 cases of BPH patients with dysurination diagnosedby pathological examination had been analyzed. Results 72.41% of all cases PSA<10ng/ml and a littlehigher than the normal reference value but had no relation to the age (P>0.05). PSA value per gram ofhyperplastic tissue of 44specimens of open prostatectomy was 0.21ng/ml. 60.09% of all the adenoma weight P<50g, and the PAS value had some postitive relation with the increasing of adenomatous weight(P<0.05).Other than the cases of only BPH change observed, 48.82% accompanied with precancerous changes.Conclusions Althrough there is a little increase of PSA in BPH cases but have no clinical diagnostic valuebecause confused by many factors. The real significance of PSA are to differentiate and early diagnose theprostatic cancer.
