银屑病患者红细胞免疫功能的研究

A study on the immune function of erythrocyte in patients with psoriasis

目的：明确银屑病特别是该病病情波动与红细胞免疫功能变化的关系。方法：检测123例银屑病患者和35例正常人E－C3bRR、E－ICR，对其中58例患者4周后作随访检测。结果：（1）银屑病患者E－C3bRR、E－ICR均较正常人高；（2）病程5年以上组较5年以下组病人的E－C3bRR高；（3）PASI与E－C3bRR呈正相关；（4）PASI的治疗前后变化值与E－C3bRR变化值呈正相关。结论：银屑病患者红细胞免疫功能存在亢进和紊乱。红细胞免疫粘附功能试验可作为判断银屑病病情和预后的客观指标之一。

Objectives: To determine the immune function of erythrocyte of patients with psoriasis, especially the relatonship between that and clinical activity of the disease. Methods: The levels of E - C3bRR and E - ICR(erythrocyticyeast rosettes)were determined in the sera of 123 patients with psoriasis and 35 healthy people, and skin lesion area as well as its severity index(PASI)were also evaluated. After 4 weeks, 58 of 123 patients were followed clinically and serologically. Results: 1) The E - C3bRR and E-ICR levels in psoriasis patients were observed to be higher than that of healthy volunteers; 2)The level of E-3bRR in the patents with a disease duraion of more than 5 years was also higher when compared to that with a disease duration of less than 5 years; 3)The PASI was positively correlated to E-C3bRR,but not to E - ICR; 4)The variation of PASI(the value of PASI before treatment minus that after treatment)was positively correlated to E - C3bRR, yet not to E-ICR. Conclusions: The immune function of erythrocyte in psoriasis patients was found to be sthenic and turbulent, and could likely be served as an objective indicator in evaluating the clinical activity and predicting the prognosis of the disease.