硒霜对小鼠皮肤GSH-Px活性影响的研究

A Study on the effect of selenium cream on GSH-Px activity of the skin of mice

目的：通过局部外用不同浓度的硒霜，观察对小鼠皮肤GSH－Px活性的影响。方法：分别以0％（对照组）、0.5％、1.0％、1．5％硒霜涂抹4组小鼠尾部皮肤，日1次，持续7或14天，观察局部皮肤反应情况，同时取皮肤组织测GSH－Px活性。结果：连续涂抹7天观察局部皮肤无明显刺激现象，1．5％硒霜组的皮肤GSH－Px活性为2．7000±0．5484，明显高于对照组的1．3467±0．6088（t=5．9486p＜0．05）。结论：1．5％硒霜局部外用可明显提高皮肤的GSH－Px活性，且无明显局部皮肤刺激症状。

Objective: To observe the efficacy of selenium cream with different concentration on GSH-Px activity of skin of mice. Methods: The tail skin of 4 groups of mice were rubbed once a day with 0%(control group), 0.5%, 1.0%, and 1.5% selenium cream respectively for 7 or 14 days. Skin reaction was observed and skin biopsy was taken for the assessment of GSH-Px activity. Results: At 7 days no stimulated response of the skin was observed, but the GSH-Px activity (2.7000±0.5484) of the skin taken from the 4th group of mice(with 1.5% selenium cream locally)was observed to be much higher (t=5.9486, p < 0.05)than that of the control group (1.3467 ± 0.6088), Conclusion: Local use of 1.5% selenium cream may remarkably increase GSH-Px activity of the skin without local reaction to seleuium cream.