摘要
目的 探讨血桨β-血小板球蛋白(β-TG)、血小板4因子(PF_4)在急性脑梗死(ACI)和多灶性脑梗死病人中的动态变化。方法 采用酶标免疫测定法测定40例 ACI 患者6-72h、7天和33例多灶性脑梗死患者及30例对照组血浆β-TG、PF_4的变化。结果 发现 ACI 组6-72hβ-TG 和 PF_4、7天后 PF_4及多灶性脑梗死组 PF_4均高于对照组(P<0.01),且 ACI 组7天后 PF_4较6-72h 显著下降(P<0.01),但仍高于对照组(P<0.01);ACI 组7天后β-TG 与多灶性脑梗死组、对照组均无差异(P>0.05)。这些变化与病灶面积的大小无明显正相关,多灶性脑梗死组病灶数目愈多、PF_4愈高(P<0.05)。结论 结果提示脑梗死病人血小板活性增高,β-TC、PF_4均升高可能为发病在6-72h 的 ACI 患者,仅有 PF_4升高可能为多灶性脑梗死。因此,可将血浆β-TG、PF_4的改变,作为缺血性脑血管病分类判断指标之一。
Objective To study the motional changes between β-thromboglobulin(β-TG)、plate-let factor 4(PF_4)in plasma and the patients with acute cerbral infarction(ACI)and multi-focus cerebral in-farction.Methods The research adopted Enzyme Immunological Assay to measure levels of plasma β-TG、PF_4 in 40 within 6-72h and 7 days later after the onset of ACI、33 multi-focus cerebral infarction patientsand 30 control group.Results Compared to the control group,β-TG,PF_4 in ACI within 6-72h,PF_4 after7 days and PF_4 in multi-focus cerbral infarction are all higher(P<0.01),but PF_4 in ACI after 7 days is obvi-ously slower than that in 6-72h(P<0.01).And also,levels of plasma β-TG in ACI after 7 days、multi-focus cerebral infarction and the control group were not obviously different(P>0.05).These changes and si-zes of focus were not positively correlated.The more focus in multi-focus cerebral infarction is,the higher PF_4is(P>0.05)。Conclusions The study shows platelet activity of cerebrel infarction patients increases.Theelevation of β-TG、PF_4 may be the ACI patients in 6-72h,only the increase in plasma PF_4 may be multi-fo-cus cerebral infarction.So,the levels of plasma β-TG、PF_4 can be one of the decisive indexes of classifica-tion in ischemic cerebrovascular disease.
